Bioactivity of Trigonella foenum (Fenugreek) oil on immunological and biochemical response of Schistosoma mansoni infected miceBioactivity of Trigonella foenum (Fenugreek) oil on immunological and biochemical response of Schistosoma mansoni infected mice

The effect of fenugreek oil (FO) on some parasitological, immunological, and biochemical parameters in mice infected with Schistosoma mansoni were investigated. Chromatography mass spectrometry (GC/MS) analysis FO revealed that linoleic acid, (E,E)-4­decadienal, isopropyl myristate are the major constituents FO. results showed treatment S. mansoni-infected 0.15 ml daily for 10 successive days exhibited a significant reduction number male worms, coupled worms as compared to an control group (p<0.05). Regarding total egg counts oogram patterns, effectively reduced percentage hepatic intestinal counts, elevated immature dead eggs ratios closely praziquantel (PZQ) treated mice. Meanwhile, significantly levels glutathione co-enzyme Q-10 (COQ-10) up 0.33±0.02 ng/ml 0.28±0.02 ng/ml, respectively. However, when accompanied PZQ, COQ-10 level was closer normal (0.37 ± 0.021 ng/ml). result also lipid per-oxidation (0.165±0.01 ng/ml) vascular endothelial growth factor (0.25±0.02 pg/ml) PZQ-treated (0.234±0.02 0.31±0.008 pg/ml, respectively). Moreover, recovered values caspase-7, annexin-V reduced. PZQ led increase It can be concluded may have potential anti-schistosomal, antioxidant anti-inflammatory activities. Also, it recovering apoptotic toward values.